Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions

Author(s)

Hirabara, Sandro M. ; Gorjao, Renata ; Vinolo, Marco A. ; Rodrigues, Alice C. ; Nachbar, Renato T. ; Curi, Rui

• Document type: Journal article
• Source: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; v. N/A, p. 16-pg., 2012-01-01.

Abstract

Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions. (AU)

• FAPESP's process: 11/05876-6 - Role of microRNAs in the development of insulin resistance
• Grantee: Alice Cristina Rodrigues
• Support Opportunities: Research Grants - Young Investigators Grants