Antifungal Applications of Ag-Decorated Hydroxyapatite Nanoparticles

Author(s)

Zamperini, C. A. ; Andre, R. S. ; Longo, V. M. ; Mima, E. G. ; Vergani, C. E. ; Machado, A. L. ; Varela, J. A. ; Longo, E.

• Document type: Journal article
• Source: Journal of Nanomaterials; v. 2013, p. 9-pg., 2013-01-01.

Abstract

Pure hydroxyapatite (HA) and hydroxyapatite decorated with silver (HA@Ag) nanoparticles were synthesized and characterized. The antifungal effect of HA@Ag nanoparticles in a distilled water solution was evaluated against Candida albicans. The origin of the antifungal activity of the HA@Ag is also discussed. The results obtained showed that the HA nanorod morphology remained the same with Ag ions decorations on the HA structure which were deposited in the form of nanospheres. Interaction where occurred between the structure and its defect density variation in the interfacial HA@Ag and intrafacial HA region with the fungal medium resulted in antifungal activity. The reaction mechanisms involved oxygen and water adsorption which formed an active complex cluster. The decomposition and desorption of the final products as well as the electron/hole recombination process have an important role in fungicidal effects. (AU)

• FAPESP's process: 11/24004-0 - Synthesis, characterization and antimicrobial properties of TiO2 and TiO2:Ag nanoparticle solutions and antimicrobial effect of inorganic biomaterials coated with these nanoparticles
• Grantee: Ana Lucia Machado
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/06786-0 - Synthesis, characterization and antimicrobial properties of TiO2 and TiO2:Ag nanoparticles solutions and antimicrobial effect of biomaterials coated with TiO2 and TiO2:Ag nanoparticles.
• Grantee: Camila Andrade Zamperini Navarro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral