Joint use of microwave and glycerol-zinc (II) acetate catalytic system in the synthesis of 2-pyridyl-2-oxazolines

Author(s)

Carmona, Rafaela C. ; Schevciw, Evelyn P. ; Petrarca de Albuquerque, Joao L. ; Wendler, Edison P. ; Dos Santos, Alcindo A.

• Document type: Journal article
• Source: GREEN PROCESSING AND SYNTHESIS; v. 2, n. 1, p. 8-pg., 2013-02-01.

Abstract

Glycerol combined with zinc (II) acetate catalyzed the reaction of 2-amino alcohols and 2-cyanopyridines under microwave irradiation, resulting in 2-pyridyl-2-oxazolines. Comparing the conversion to that obtained by conventional heating, a significant decrease in the reaction time was achieved. At the end of the reaction, the product was isolated and the glycerol-zinc (II) acetate catalytic system was recycled four times for the same transformation in reasonable to acceptable yields. The products were obtained in their pure form by simple filtration in a short pad of silica. (AU)

• FAPESP's process: 08/55401-1 - Preparation and application of chiral compounds containing chalcogens
• Grantee: João Valdir Comasseto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 11/11613-8 - A3-coupling reactions on the synthesis of bioactive nitrogen containing compounds
• Grantee: Alcindo Aparecido dos Santos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/03244-2 - Asymmetric strategies in A-3 coupling eactions
• Grantee: Rafaela Costa Carmona
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/17093-9 - A3-Coupling reactions on the synthesis of Codonopsinine and Monomorine I
• Grantee: João Luiz Petrarca de Albuquerque
• Support Opportunities: Scholarships in Brazil - Scientific Initiation