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EFFECT OF FLUORIDE INTAKE ON CARBOHYDRATE METABOLISM, GLUCOSE TOLERANCE, AND INSULIN SIGNALING

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Author(s):
Chiba, Fernando Yamamoto ; Saliba Garbin, Clea Adas ; Sumida, Doris Hissako
Total Authors: 3
Document type: Journal article
Source: FLUORIDE; v. 45, n. 3, p. 6-pg., 2012-07-01.
Abstract

Fluoride is known to cause both local and systemic alterations in animals and humans, such as dental fluorosis and disturbances in glucose homeostasis. The effects of fluoride are dose dependent and can produce decreased insulin secretion, inhibition of glycolysis, glycogen depletion, hyperglycemia, and insulin resistance. Because excessive ingestion of fluoride during tooth brushing can lead to deterioration in health, the use of low-fluoride dentifrices is recommended for young children with diabetes. (AU)

FAPESP's process: 10/10664-5 - EVALUATION OF THE INSULIN SIGNAL INHIBITORY PATHWAY IN RATS CHRONICALLY TREATED WITH SODIUM FLUORIDE
Grantee:Fernando Yamamoto Chiba
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/00086-7 - Assessment of insulin signal in rat chronically treated with sodium fluoride
Grantee:Doris Hissako Matsushita
Support Opportunities: Regular Research Grants