Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Author(s)

Pezato, Rogerio ; de Almeida, Danilo Candido ; Bezerra, Thiago Freire ; Silva, Fernando de Sa ; Perez-Novo, Claudina ; Gregorio, Luis Carlos ; Voegels, Richard Louis ; Camara, Niels Olsen ; Bachert, Claus

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2014, p. 11-pg., 2014-01-01.

Abstract

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+ CD25+ Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition. (AU)

• FAPESP's process: 10/12295-7 - MicroRNA profile during the repair of cisplatin-induced renal tissue and cells injury by therapy with mesenchymal stem cells derived from adipose tissue.
• Grantee: Danilo Candido de Almeida
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants