An HIV-1 Transmission Case Possibly Associated with Manicure Care

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Author(s):	Matsuda, Elaine Monteiro ; Ozorio Coelho, Luana Portes ; Pimentel, Victor Figueiredo ; Onias, Humberto Barjud ; de Macedo Brigido, Luis Fernando Total Authors: 5
Document type:	Journal article
Source:	AIDS Research and Human Retroviruses; v. 30, n. 11, p. 4-pg., 2014-11-01.
Abstract
A recently diagnosed 22-year-old female with no history of transmission risk factors prompted a thorough investigation of possible alternative risk factors. As the patient had evidence of advanced disease and laboratory data compatible with long-standing infection, past events were reviewed. About 10 years ago the patient shared manicure utensils with an older cousin, later known to be HIV infected; this prompted the phylogenetic analysis of the HIV sequences of both patients. Phylogenetic analyses of partial HIV-1 polymerase and envelope sequences from both patients revealed highly related sequences, with an estimated common ancestor date (about 11 years ago) that coincided with the putative sharing of manicure instruments, during a time in which the cousin was not virally suppressed. Taken together, the information about the infection of this patient suggests the use of shared manicure instruments as an alternative route of fomite HIV-1 transmission. (AU)

FAPESP's process:	11/21958-2 - Genetic resistance to HIV-1 in the salvage therapy with new antiretroviral drug classes
Grantee:	Luís Fernando de Macedo Brígido
Support Opportunities:	Regular Research Grants