| Full text | |
| Author(s): Show less - |
Lopes, Mariana Pezzute
;
Nunes Santos, Magnun Nueldo
;
Faber, Eliel Wagner
;
Cavalcanti Bezerra, Marcos Andre
;
Domingues Hatzlhofer, Betania Lucena
;
Albuquerque, Dulcineia Martins
;
Zaccariotto, Tania Regina
;
Ribeiro, Daniela Maria
;
Araujo, Aderson da Silva
;
Costa, Fernando Ferreira
;
Sonati, Maria de Fatima
Total Authors: 11
|
| Document type: | Journal article |
| Source: | DISEASE MARKERS; v. 2014, p. 4-pg., 2014-01-01. |
| Abstract | |
Background. Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5 Delta 32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less efficient Th1 response. We determined the frequency of the CCR5 Delta 32 polymorphism in 795 Afro-Brazilian SCD patients followed up at the Pernambuco Hematology and Hemotherapy Center, in Northeastern Brazil, divided into a pediatric group (3 months-17 years, n = 483) and an adult group (18-70 years, n = 312). The adult patients were also compared to a healthy control group (blood donors, 18-61 years, n = 247). Methods. The CCR5/CCR5 Delta 32 polymorphism was determined by allele-specific PCR. Results. No homozygous patient for the CCR5 Delta 32 allele was detected. The frequency of heterozygotes in the study population (patients and controls) was 5.8%, in the total SCD patients 5.1%, in the children 5.4%, in the adults with SCD 4.8%, and in the adult controls 8.1%. These differences did not reach statistical significance. Conclusions. Our findings failed to demonstrate an important role of the CCR5 Delta 32 allele in the population sample studied here. (AU) | |
| FAPESP's process: | 08/57441-0 - Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias |
| Grantee: | Fernando Ferreira Costa |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/02622-3 - Inflammatory aspects versus haptoglobin and hemopexin genotypes and presence of the ccr5d32 polymorphism in sickle cell anemia patients |
| Grantee: | Maria de Fatima Sonati |
| Support Opportunities: | Regular Research Grants |