Synthesis of 1,3,4-oxadiazole derivatives from alpha-amino acid and acyl hydrazides under thermal heating or microwave irradiation conditions

Author(s)

Dornelles, Luciano ; Rodrigues, Oscar E. D. ; Heck, Elisiane F. ; Bender, Caroline R. ; Cansian, Mariane B. ; Schwab, Ricardo S. ; Severo Filho, Wolmar A.

• Document type: Journal article
• Source: ARKIVOC; v. N/A, p. 14-pg., 2015-01-01.

Abstract

A series of new 2,5-disubstituted 1,3,4-oxadiazoles was synthesized under conventional thermal heating and microwave irradiation conditions through the reaction of acyl hydrazides with N-protected a-amino acid in presence of a small amount of POCl3. Heterocycles were obtained in moderate to good yields and in relatively short reaction times. (AU)

• FAPESP's process: 13/06558-3 - Asymmetric catalysis: preparation of chiral alcohols and their derivatives from highly functionalized organozinc reagents and application of new chiral ligands supported on magnetic nanoparticles
• Grantee: Ricardo Samuel Schwab
• Support Opportunities: Regular Research Grants