Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N '-acyl thiourea complexes

Author(s)

Plutin, Ana M. ; Alvarez, Anislay ; Mocelo, Raul ; Ramos, Raul ; Castellano, Eduardo E. ; da Silva, Monize M. ; Colina-Vegas, Legna ; Pavan, Fernando R. ; Batista, Alzir A.

• Document type: Journal article
• Source: Inorganic Chemistry Communications; v. 63, p. 7-pg., 2016-01-01.

Abstract

Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N'-acyl thiourea complexes with general formulae [Pt(dppf)(L)]PF6, [dppf = 1,1'-bis (diphenylphosphino)ferrocene; L = N,N-disubstituted-N'-acyl thioureas] is reported. The complexes were characterized by elemental analysis, molar conductivity, IR, NMR (H-1, C-13 and P-31{H-1}) spectroscopy. The spectroscopic data are consistent with the complexes containing one dppf and one O, S chelated ligand. The crystal structures of complexes with N,N-diphenyl-N'-benzoylthiourea (L4), N,N-diethyl-N'-furoylthiourea (L5) and N,N-diphenyl-N'-(thiophene-2-carbonyl)thiourea (L8) were determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar structures. The complexes were screened with respect to their anti-M. tuberculosis activity (H37Rv ATCC 27294). (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 13/14957-5 - Research potential against tuberculosis of a new class of furoxan compounds and nanostructured compounds of the ruthenium(II) and copper (II)
• Grantee: Fernando Rogério Pavan
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/13691-4 - The crystallography as tool in the help to elucidate the mechanism of action of potential metallodrugs
• Grantee: Eduardo Ernesto Castellano
• Support Opportunities: Regular Research Grants