| Full text | |
| Author(s): |
Calvo, Adriana Maria
;
de Oliveira Prado, Mariel Tavares
;
Dionisio, Thiago Jose
;
Marques, Maria Paula
;
Brozoski, Daniel Thomas
;
Lanchote, Vera Lucia
;
Cardoso Faria, Flavio Augusto
;
Santos, Carlos Ferreira
Total Authors: 8
|
| Document type: | Journal article |
| Source: | BRAZILIAN ORAL RESEARCH; v. 30, n. 1, p. 6-pg., 2016-01-01. |
| Abstract | |
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de Sao Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers. (AU) | |
| FAPESP's process: | 13/18454-8 - Influence of genotype of cytochrome P450 (CYP2C9) on pharmacokinetics of piroxicam |
| Grantee: | Mariel Tavares de Oliveira Prado Bergamo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 09/17851-8 - Influence of cytochrome P450 (CYP2C9) genotype on the clinical efficacy and pharmacokinetics of piroxicam after lower third molar surgery |
| Grantee: | Adriana Maria Calvo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |