Mitochondrial form, function and signalling in aging

Author(s)

Amigo, Ignacio ; da Cunha, Fernanda M. ; Forni, Maria Fernanda ; Garcia-Neto, Wilson ; Kakimoto, Pamela A. ; Luevano-Martinez, Luis A. ; Macedo, Felipe ; Menezes-Filho, Sergio L. ; Peloggia, Julia ; Kowaltowski, Alicia J.

• Document type: Journal article
• Source: Biochemical Journal; v. 473, p. 29-pg., 2016-10-01.

Abstract

Aging is often accompanied by a decline in mitochondrial mass and function in different tissues. Additionally, cell resistance to stress is frequently found to be prevented by higher mitochondrial respiratory capacity. These correlations strongly suggest mitochondria are key players in aging and senescence, acting by regulating energy homeostasis, redox balance and signalling pathways central in these processes. However, mitochondria display a wide array of functions and signalling properties, and the roles of these different characteristics are still widely unexplored. Furthermore, differences in mitochondrial properties and responses between tissues and cell types, and how these affect whole body metabolism are also still poorly understood. This review uncovers aspects of mitochondrial biology that have an impact upon aging in model organisms and selected mammalian cells and tissues. (AU)

• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 13/04919-9 - Evaluation of the adaptive response of mitochondrial membranes to stress: role of cardiolipin in membrane plasticity, dynamics and pathological situations
• Grantee: Luis Alberto Luevano Martinez
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/15526-3 - Study of the involvement of mitochondrial activity in the super-response to caloric restriction in Caenorhabditis elegans mutants for lipl-5
• Grantee: Fernanda Marques da Cunha
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/17270-3 - Impact of mitochondrial dysfunction on skin aging
• Grantee: Julia Peloggia de Castro
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 10/51906-1 - Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism
• Grantee: Alicia Juliana Kowaltowski
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/25776-7 - Mitochondrial Partitioning in Mammalian Cells.
• Grantee: Maria Fernanda Pereira de Araújo Demonte Forni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral