| Full text | |
| Author(s): |
Damasceno, Jeziel D.
;
Silva, Gabriel L. A.
;
Tschudi, Christian
;
Tosi, Luiz R. O.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Memórias do Instituto Oswaldo Cruz; v. 112, n. 8, p. 5-pg., 2017-08-01. |
| Abstract | |
The Telomeric Repeat- containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes. (AU) | |
| FAPESP's process: | 13/00570-1 - Characterization of the putative 9-1-1 complex of Leishmania major |
| Grantee: | Jeziel Dener Damasceno |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/06824-8 - Characterization of the proteins LmRad9 and LmRad1 in the DNA damage response of Leishmania major |
| Grantee: | Luiz Ricardo Orsini Tosi |
| Support Opportunities: | Regular Research Grants |