Description and evaluation of experimental models for uterine transplantation in pigs

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Author(s):	de Oliveira, Emerson ; da Silva Tavares, Kelly Alessandra ; Vieira Gomes, Mariano Tamura ; Salzedas-Netto, Alcides Augusto ; Ferreira Sartori, Marair Gracio ; Castro, Rodrigo Aquino ; Fernandes, Cesar Eduardo ; Batista Castello Girao, Manoel Joao Total Authors: 8
Document type:	Journal article
Source:	Einstein (São Paulo); v. 15, n. 4, p. 5-pg., 2017-10-01.
Abstract
Objective: To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression. Methods: We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood incompatibility. Hysterectomy was performed in the donor under general anesthesia, with the removal of the aorta and inferior vena cava in monobloc, and anastomosis of these vessels was made in the recipient. Results: Six experiments were performed, and on the immediate postoperative period, five animals had good reperfusion. However, on the seventh postoperative day, histological analysis showed rejection in five animals. Conclusion: The experimental model of uterine transplantation is feasible, but monitoring doses of immunosuppressants is pivotal to prevent rejection episodes. (AU)

FAPESP's process:	08/09441-1 - Description and evaluation of experimental models for uterine transplantation in rabbits
Grantee:	Emerson de Oliveira
Support Opportunities:	Scholarships in Brazil - Post-Doctoral