Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Author(s)

Yamashita, Alex S. ; Belchior, Thiago ; Lira, Fabio S. ; Bishop, Nicolette C. ; Wessner, Barbara ; Rosa, Jose C. ; Festuccia, William T.

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2018, p. 18-pg., 2018-01-01.

Abstract

Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic beta-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic beta-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation. (AU)

• FAPESP's process: 15/22983-1 - Discovery of new transcription factors involved in the development of steatosis, steatohepatitis, and liver cancer
• Grantee: Thiago Belchior de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/15825-5 - SEARCHING NEW THERAPIES FOR INSULIN RESISTANCE: DEVELOPMENT OF A PLATFORM FOR DRUG SCREENING AND PRECLINICAL IN VIVO ASSAY
• Grantee: Alex Shimura Yamashita
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/19530-5 - Involvement of the nutrient sensor mTOR in the development of obesity associated chronic metabolic diseases
• Grantee: William Tadeu Lara Festuccia
• Support Opportunities: Research Projects - Thematic Grants