Mitoimmunitywhen mitochondria dictates macrophage function

Author(s)

Correa-da-Silva, Felipe ; Pereira, Jessica A. S. ; de Aguiar, Cristhiane F. ; de Moraes-Vieira, Pedro M. M.

• Document type: Journal article
• Source: Cell Biology International; v. 42, n. 6, p. 5-pg., 2018-06-01.

Abstract

In the past decade, several reports have appointed the importance of mitochondria in the immune response. Our understanding of mitochondria evolved from a simple supplier of energy into a platform necessary for immunorregulation. Proinflammatory responses are associated with enhanced glycolytic activity and breakdown of the TCA cycle. Mitochondrial reactive species of oxygen (mROS) are key regulators of classically activated macrophages, with substantial impact in the anti-microbicidal activity and pro-inflammatory cytokine secretion of macrophages. The inflammasome activation in macrophages is dependent on mROS production and mitochondrial regulation and mitochondrial dynamics and functionality direct impact inflammatory responses. Alternative activated macrophage metabolism relies on fatty acid oxidation, and the mechanism responsible for this phenotype is not fully elucidated. Thus, cellular metabolism and mitochondria function is a key immunoregulatory feature of macrophage biology. In this review, we will provide insights into recently reported evidences of mitochondria-related metabolic nodes, which are important for macrophage physiology. (AU)

• FAPESP's process: 15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases
• Grantee: Pedro Manoel Mendes de Moraes Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/06225-5 - Influence of synthetic ([Nle 4, D-Phe7] -±-MSH on microglia metabolism: possible implications on obesity development
• Grantee: Felipe Corrêa da Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/12848-5 - Studying NKT cell metabolism in obesity and metabolic syndrome
• Grantee: Cristhiane Favero de Aguiar
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/00079-7 - Effects of LXRs receptor activation on systemic metabolic parameters and on the metabolic modulation of resident tissue macrophages of adipose tissue
• Grantee: Jéssica Aparecida da Silva Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate