Scholarship 17/06225-5 - Hipotálamo, Imunometabolismo - BV FAPESP
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Influence of synthetic ([Nle 4, D-Phe7] -±-MSH on microglia metabolism: possible implications on obesity development

Grant number: 17/06225-5
Support Opportunities:Scholarships in Brazil - Master
Start date until: August 01, 2017
End date until: December 31, 2019
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Pedro Manoel Mendes de Moraes Vieira
Grantee:Felipe Corrêa da Silva
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases, AP.JP
Associated scholarship(s):18/12257-0 - Hypothalamic neuropeptides as microglial immunoregulators, BE.EP.MS

Abstract

The comprehension of the molecular mechanisms involved in the genesis of obesity and the possibility reversing the obese phenotype is extremely relevant for the prevention and treatment of this pathology and its comorbidities. The global metabolic control, in mammals, is performed by the hypothalamus, a central nervous system structure. Neuronal populations in the hypothalamus are able to sense blood borne signals which indicate the organism nutrional status which involves insulin and leptin signaling. The feeding of diets rich in satureted fatty acids leads to hypothalamic inflammation and anorexigenic signaling impairment. This impairiment is a direct result of POMC (Pro-opiomelanocortin) + neurons death and its disfunction, which is triggered by tissue inflammation. ±-MSH (alpha-melanocyte stimulating hormone) is one of the peptides obtained from POMC cleavage. ±-MSH acts on membrane receptors called melanocortin receptors. In the central nervous system, the melanocortin receptor 3 4 are broadly expressed, and are the most relevant ±-MSH receptors for energy homeostasis. In addition to its function in metabolic control, ±-MSH also has a marked anti-inflammatory role directly on imune cells. Here, we hypothesize that the dysfunction of POMC+ neurons is required for the perpetuation and intensification of hypothalamic inflammation, which may be attributed to the diminished ±-MSH signaling in microglia. Our aim is to investigate the anti-inflammatory effects of ±-MSH on microglial. For this purpose, we will study the immune and metabolic phenotype of microglial cells. We expect that ±-MSH treatment will induce an anti-inflammatory phenotype in microglial cells, which may be dependent on the metabolic status of the microglia. This may result in attenuation of metabolic inflammation. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA PEREIRA, JESSICA APARECIDA; DA SILVA, FELIPE CORREA; MENDES DE MORAES-VIEIRA, PEDRO MANOEL. The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. JOURNAL OF DIABETES RESEARCH, . (15/15626-8, 17/06225-5)
DOS REIS, LARISSA MENEZES; ADAMOSKI, DOUGLAS; OLIVEIRA SOUZA, RODOLPHO ORNITZ; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; CORREA-DA-SILVA, FELIPE; DE SA PATRONI, FABIO MALTA; DIAS, MARILIA MEIRA; CONSONNI, SILVIO ROBERTO; MENDES DE MORAES-VIEIRA, PEDRO MANOEL; et al. Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells. Journal of Biological Chemistry, v. 294, n. 24, p. 9342-9357, . (15/15626-8, 14/17820-3, 15/25832-4, 14/18061-9, 15/26059-7, 16/06034-2, 17/06225-5, 13/23510-4, 14/06512-6, 14/15968-3)
CORREA-DA-SILVA, FELIPE; PEREIRA, JESSICA A. S.; DE AGUIAR, CRISTHIANE F.; DE MORAES-VIEIRA, PEDRO M. M.. Mitoimmunitywhen mitochondria dictates macrophage function. Cell Biology International, v. 42, n. 6, p. 5-pg., . (15/15626-8, 17/06225-5, 17/12848-5, 17/00079-7)
CORREA-DA-SILVA, FELIPE; PEREIRA, JESSICA A. S.; DE AGUIAR, CRISTHIANE F.; DE MORAES-VIEIRA, PEDRO M. M.. Mitoimmunitywhen mitochondria dictates macrophage function. Cell Biology International, v. 42, n. 6, SI, p. 651-655, . (15/15626-8, 17/12848-5, 17/06225-5, 17/00079-7)
DA SILVA, FELIPE CORREA; AGUIAR, CRISTHIANE; PEREIRA, JESSICA A. S.; MONTEIRO, LAUAR DE BRITO; DAVANZO, GUSTAVO GASTAO; CODO, ANA CAMPOS; DE FREITAS, LEONARDO PIMENTEL; BERTI, ALINE SIQUEIRA; FERRUCCI, DANILO LOPES; CASTELUCCI, BIANCA GAZIERI; et al. Ghrelin effects on mitochondrial fitness modulates macrophage function. Free Radical Biology and Medicine, v. 145, p. 61-66, . (17/23679-0, 16/18031-8, 17/12848-5, 18/22505-0, 15/15626-8, 17/00079-7, 17/06225-5)
DA SILVA PEREIRA, JESSICA APARECIDA; DA SILVA, FELIPE CORREA; MENDES DE MORAES-VIEIRA, PEDRO MANOEL. The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective. JOURNAL OF DIABETES RESEARCH, v. 2017, p. 15-pg., . (15/15626-8, 17/06225-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Felipe Corrêa da. Role of a-MSH on microglial cells: immunometabolic implications. 2019. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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