| Full text | |
| Author(s): |
Markus, Regina P.
;
Fernandes, Pedro A.
;
Kinker, Gabriela S.
;
Cruz-Machado, Sanseray da Silveira
;
Marcola, Marina
Total Authors: 5
|
| Document type: | Journal article |
| Source: | British Journal of Pharmacology; v. 175, n. 16, p. 12-pg., 2018-08-01. |
| Abstract | |
Melatonin is well known for its circadian production by the pineal gland, and there is a growing body of data showing that it is also produced by many other cells and organs, including immune cells. The chronobiotic role of pineal melatonin, as well as its protective effects in vitro and in vivo, have been extensively explored. However, the interaction between the chronobiotic and defence functions of endogenous melatonin has been little investigated. This review details the current knowledge regarding the coordinated shift in melatonin synthesis from the pineal gland (circadian and monitoring roles) to the regulation of acute immune responses via immune cell production and autocrine effects, producing systemic interactions termed the immune-pineal axis. An acute inflammatory response drives the transcription factor, NFB, to switch melatonin synthesis from pinealocytes to macrophages/microglia and, upon acute inflammatory resolution, back to pinealocytes. The potential pathophysiological relevance of immune-pineal axis dysregulation is highlighted, with both research and clinical implications, across several medical conditions, including host/parasite interaction, neurodegenerative diseases and cancer. (AU) | |
| FAPESP's process: | 14/27287-0 - Characterization of the melatonergic system of human gliomas and its implication on tumor aggressiveness and invasiveness |
| Grantee: | Gabriela Sarti Kinker |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 15/04557-5 - The activation of immune-pineal axis by high-fat diet |
| Grantee: | Sanseray da Silveira Cruz Machado |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/52687-1 - Characterization of the role of adrenal/pineal interaction in the immune-pineal axis context |
| Grantee: | Pedro Augusto Carlos Magno Fernandes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/13691-1 - Immune-pineal axis: time-niology integrated to surveillance and defense |
| Grantee: | Regina Pekelmann Markus |
| Support Opportunities: | Research Projects - Thematic Grants |