Seroconversion for Cytomegalovirus Infection During Pregnancy and Fetal Infection in a Highly Seropositive Population: "The BraCHS Study"

Author(s)

Mussi-Pinhata, Marisa M. ; Yamamoto, Aparecida Y. ; Aragon, Davi C. ; Duarte, Geraldo ; Fowler, Karen B. ; Boppana, Suresh ; Britt, William J.

• Document type: Journal article
• Source: Journal of Infectious Diseases; v. 218, n. 8, p. 5-pg., 2018-10-15.

Abstract

We determined the risk of seroconversion in seronegative pregnant women living in a high seroprevalence population. Cytomegalovirus (CMV)-immunoglobulin G reactivity was determined at the 1st trimester in all women and sequentially for seronegative women. A total of 1915 of 1952 (98.1%; 95% confidence interval [CI], 97.4%-98.7%) women were seropositive, and 36 (1.8%; 95% CI, 1.3%-2.6%) were seronegative. Five of the 36-seronegative women seroconverted for a cumulative rate of 13.9% (95% CI, 4.8%-30.6%). Congenital CMV infection was diagnosed in 1 of 36 infants (2.8%; 95% CI, 0.5%-63.9%) born to seronegative women compared with 8 of 1685 (0.5%; 95% CI, 0.2%-1.0%) infants born to seropositive mothers. Even with a high risk of primary infection in seronegative women, most CMV-infected infants were born to women with pre-existing seroimmunity. (AU)

• FAPESP's process: 13/06579-0 - Brazilian congenital cytomegalovirus, hearing and maternal secondary infection study (BraCHS Study)
• Grantee: Marisa Marcia Mussi
• Support Opportunities: Research Projects - Thematic Grants