Brazilian congenital cytomegalovirus, hearing and maternal secondary infection study (BraCHS Study)

• Grant number: 13/06579-0
• Support Opportunities: Research Projects - Thematic Grants
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Marisa Marcia Mussi
• Grantee: Marisa Marcia Mussi
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Aparecida Yulie Yamamoto
• Associated researchers: Adriana Ribeiro Tavares ; Ana Cláudia Mirândola Barbosa Reis ; Eduardo Tanaka Massuda ; Geraldo Duarte ; Myriam de Lima Isaac ; Victor Evangelista de Faria Ferraz ; Wilson Araújo da Silva Junior
• Associated scholarship(s): 13/26767-6 - Genome variation of human cytomegalovirus: longitudinal and at birth analysis of viral strains from congenitally infected infants, BP.PD

Abstract

Human cytomegalovirus (CMV) infection represents the most common viral infection transmitted in-utero and is a significant cause of developmental disorders in children. The rate of congenital HCMV infection ranges from 0.2-1.0%. Although our research group has already elucidated some aspects of this infection among us - such as the frequent occurrence of infection among live birth infants and disease in the infected ones, including sensorineural hearing loss after non-primary maternal infection- several crucial questions with respect to the natural history of congenital CMV infection remain unanswered. This is particularly true for populations with high viral immunity such as the Brazilian one because infection and transmission in women with existing immunity to this virus are frequent. In this proposal, we will prospectively evaluate a cohort of approximately 4000 pregnant women from the first trimester gestation and a cohort of 9000 newborns. Women will be evaluated 3 times during gestation and once after delivery and babies with hearing loss and/or infected with CMV will be followed until at least one year of age. We intend to define virological and immunological characteristics of non-primary infections in pregnant women from a highly seroimmune population in which non-primary maternal infections account for the vast majority of infected babies. We will analyze the CMV genomic diversity, evaluating the viral dynamics and its relationship with disease. We will also determine the incidence of the most common long term sequelae of congenital HCMV infection, hearing loss, in infected babies. These studies could aid in the rationale development of effective prophylactic and possibly therapeutic vaccines to limit the morbidity from this congenital infection. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANASTASIO, ADRIANA R. T.; YAMAMOTO, APARECIDA Y.; MASSUDA, EDUARDO T.; MANFREDI, ALESSANDRA K. S.; CAVALCANTE, JULIANA M. S.; LOPES, BRUNO C. P.; ARAGON, DAVI C.; BOPPANA, SURESH; FOWLER, KAREN B.; BRITT, WILLIAM J.; et al. Comprehensive evaluation of risk factors for neonatal hearing loss in a large Brazilian cohort. Journal of Perinatology, v. 41, n. 2, SEP 2020. (13/06579-0)

BARBOSA, NAYARA G.; YAMAMOTO, APARECIDA Y.; DUARTE, GERALDO; ARAGON, DAVI C.; FOWLER, KAREN B.; BOPPANA, SURESH; BRITT, WILLIAM J.; MUSSI-PINHATA, MARISA M.. Cytomegalovirus Shedding in Seropositive Pregnant Women From a High-Seroprevalence Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study. Clinical Infectious Diseases, v. 67, n. 5, p. 743-750, SEP 1 2018. (13/06579-0)

MUSSI-PINHATA, MARISA M.; YAMAMOTO, APARECIDA Y.; ARAGON, DAVI C.; DUARTE, GERALDO; FOWLER, KAREN B.; BOPPANA, SURESH; BRITT, WILLIAM J.. Seroconversion for Cytomegalovirus Infection During Pregnancy and Fetal Infection in a Highly Seropositive Population: ``The BraCHS Study{''}. Journal of Infectious Diseases, v. 218, n. 8, p. 1200-1204, OCT 15 2018. (13/06579-0)

YAMAMOTO, APARECIDA Y.; ANASTASIO, ADRIANA R. T.; MASSUDA, EDUARDO T.; ISAAC, MYRIAM L.; MANFREDI, ALESSANDRA K. S.; CAVALCANTE, JULIANA M. S.; CARNEVALE-SILVA, ADRIANA; FOWLER, KAREN B.; BOPPANA, SURESH B.; BRITT, WILLIAM J.; et al. Contribution of Congenital Cytomegalovirus Infection to Permanent Hearing Loss in a Highly Seropositive Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study. Clinical Infectious Diseases, v. 70, n. 7, p. 1379-1384, APR 1 2020. (13/06579-0)

MUSSI-PINHATA, MARISA M.; YAMAMOTO, APARECIDA Y.; ARAGON, DAVI C.; DUARTE, GERALDO; FOWLER, KAREN B.; BOPPANA, SURESH; BRITT, WILLIAM J.. Seroconversion for Cytomegalovirus Infection During Pregnancy and Fetal Infection in a Highly Seropositive Population: "The BraCHS Study". Journal of Infectious Diseases, v. 218, n. 8, p. 5-pg., 2018-10-15. (13/06579-0)