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Retrospective cohort of pregnant exposed to the Zika virus in São José do Rio Preto in 2016

Grant number: 17/21688-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2018
Effective date (End): January 31, 2020
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Marcos Tayar Augusto
Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Associated research grant:13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM


The head circumference, longest possible fronto-occipital distance, represents the growth of the central nervous system, and may vary according to the gestational age, gender and weight of the newborn. When the head circumference is reduced, microcephaly occurs, which is a congenital malformation in which the brain does not develop properly. It is characterized by a head circumference below the third percentile expected for age and sex and, depending on its etiology, may be associated with structural malformations of the brain. Most cases of microcephaly are accompanied by motor and cognitive changes that vary according to the degree of brain involvement. In general, children are delayed in neuropsychomotor development with relevant motor and cognitive impairment and, in some cases, sensory functions (hearing and vision) are also affected. In Brazil, as of September 2015, there was a sudden increase in cases of microcephaly resulting from the onset of circulation of Zika virus (ZIKV) in the country, an infection that causes a benign disease, but which, because of its interference in the Gestation has become a public health problem. The present study intends to analyze the head circumference of live newborns that were born in the Hospital of the Child and Maternity of São José do Rio Preto in the year of 2016, analyzing the factors that can influence in this anthropometric measure and comparing the values obtained not only with global parameters, but also with results from the same population in the period prior to the circulation of ZIKV in the region. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA ALECRIM, MARIA DAS GRACAS; RAMOS DE AMORIM, MELANIA MARIA; BARRETO DE ARAUJO, THALIA VELHO; BRASIL, PATRICIA; BRICKLEY, ELIZABETH B.; CASTILHO, MARCIA DA COSTA; COELHO, BERNADETE PEREZ; LEDO ALVES DA CUNHA, ANTONIO JOSE; DUARTE, GERALDO; ESTOFOLETE, CASSIA FERNANDA; et al. Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy. Viruses-Basel, v. 13, n. 4, . (15/12295-0, 17/21688-1, 16/05115-9, 16/08578-0, 16/15021-1, 13/21719-3)

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