| Full text | |
| Author(s): |
Acevedo-Rodriguez, A.
;
Kauffman, A. S.
;
Cherrington, B. D.
;
Borges, C. S.
;
Roepke, T. A.
;
Laconi, M.
Total Authors: 6
|
| Document type: | Journal article |
| Source: | Journal of Neuroendocrinology; v. 30, n. 10, p. 11-pg., 2018-10-01. |
| Abstract | |
Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex steroid secretion and function. In addition to guiding proper gonadal development and function, gonadal sex steroids also act in negative- and positive-feedback loops to regulate reproductive circuitry in the brain, including kisspeptin neurones, thereby modulating overall HPG axis status. Additional regulation is also provided by sex steroids made within the brain, including neuroprogestins. Furthermore, because reproduction and survival need to be coordinated and balanced, the HPG axis is able to modulate (and be modulated by) stress hormone signalling, including cortiscosterone, from the hypothalamic-pituitary-adrenal (HPA) axis. This review covers recent data related to the neural, hormonal and stress regulation of the HPG axis and emerging interactions between the HPG and HPA axes, focusing on actions at the level of the brain and pituitary. (AU) | |
| FAPESP's process: | 12/25350-1 - Effects of in utero betamethasone exposure on male rats reproductive parameters, with emphasis on sperm quality and fertility: a multigenerational approach |
| Grantee: | Cibele dos Santos Borges |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/13660-1 - Effects of in utero exposure to betamethasone on puberty installation and reproductive parameters of female Wistar rats |
| Grantee: | Tainá Louise Pacheco |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |