Topical tamoxifen in the therapy of cutaneous leishmaniasis

Author(s)

Trinconi, Cristiana T. ; Reimao, Juliana Q. ; Bonano, Vivian, I ; Espada, Caroline R. ; Miguel, Danilo C. ; Yokoyama-Yasunaka, Jenicer K. U. ; Uliana, Silvia R. B.

• Document type: Journal article
• Source: Parasitology; v. 145, n. 4, p. 7-pg., 2018-04-01.

Abstract

The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Lrishmania amazonerisis were treated with topical tamoxifen in two different formulations (cthanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later. Topical tamoxifen, formulated in ethanol or as a cream, was shown to be effective. The interaction between tamoxifen and pentavalent antimonial was additive in vitro. Treatment with combined schemes containing tamoxifen and pentavalent antimonial was effective in reducing lesion size and parasite burden. Co-administration of tamoxifen and pentavalent antimonial was superior to monotherapy with antimonial. (AU)

• FAPESP's process: 11/18858-6 - TAMOXIFEN AS AN ANTI-LEISHMANIAL DRUG: ACTIVITY IN COMBINED THERAPEUTIC SCHEMES AND STUDY OF THE MECHANISM OF ACTION
• Grantee: Cristiana de Melo Trinconi Tronco
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/09080-2 - Evaluation of candidate drugs for the treatment of Leishmaniasis in Brazil
• Grantee: Silvia Reni Bortolin Uliana
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/21970-2 - SELECTIVE ESTROGEN RECEPTOR MODULATORS AS DRUG CANDIDATES FOR VISCERAL LEISHMANIASIS: EVALUATION OF DRUG COMBINATIONS AND INVESTIGATION OF LEISHMANICIDAL MECHANISMS OF ACTION
• Grantee: Juliana Quero Reimão Dalla Zanna
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/20484-7 - Tamoxifen in the treatment of leishmaniasis: evaluation of efficacy in combination therapy schemes and study of the antileishmanial mechanism of action
• Grantee: Silvia Reni Bortolin Uliana
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/05130-5 - Characterization of Leishmania (v.) braziliensis clinical isolates susceptibility to miltefosine in vitro and in vivo
• Grantee: Caroline Ricce Espada
• Support Opportunities: Scholarships in Brazil - Master