Agitation and impulsivity in mid and late life as possible risk markers for incident dementia

Author(s):Show less -

Bateman, Daniel R. ; Gill, Sascha ; Hu, Sophie ; Foster, Erin D. ; Ruthirakuhan, Myuri T. ; Sellek, Allis F. ; Mortby, Moyra E. ; Matuskova, Veronika ; Ng, Kok Pin ; Tarawneh, Rawan M. ; Freund-Levi, Yvonne ; Kumar, Sanjeev ; Gauthier, Serge ; Rosenberg, Paul B. ; de Oliveira, Fabricio Ferreira ; Devanand, D. P. ; Ballard, Clive ; Ismail, Zahinoor ; Int Soc Adv Alzheimers Res Treatme ; Neuropsychiat Syndromes Profession

• Document type: Journal article
• Source: ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS; v. 6, n. 1, p. 22-pg., 2020-01-01.

Abstract

To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (N PS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre-dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late-onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre-dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre-dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia. (AU)

• FAPESP's process: 15/10109-5 - Comparative analysis of cerebrospinal fluid and serum markers in dementia with Lewy Bodies and Alzheimer's Disease dementia
• Grantee: Fabricio Ferreira de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral