Physical and chemical properties of LDL and HDL, cardiometabolic and oxidative mar...
| Grant number: | 13/14863-0 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | January 01, 2014 |
| Effective date (End): | May 31, 2016 |
| Field of knowledge: | Health Sciences - Nutrition |
| Principal Investigator: | Nágila Raquel Teixeira Damasceno |
| Grantee: | Caroline Pappiani |
| Home Institution: | Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Cardiovascular diseases are the leading cause of morbidity and mortabilidade worldwide, and its prevalence more rapidly in low and middle income countries. Despite the reduction in the number of deaths after the discovery of statins, approximately 5% of patients develop adverse effects with the use of these drugs, which contraindicate its continued use. In addition, about 30% of individuals under statin use remain with moderate or high cardiovascular risk. Therefore, changes in lifestyle and diet in particular are an important tool in the modification of risk factors and possibly in preventing clinical events. Accordingly, the use of different fatty acids intervention is potentially interesting as previously reported in the literature. Despite this fact, the simultaneous evaluation of the effect of omega-3, omega-6 and omega-9 is still little explored in the literature and absent in the Brazilian population. The aim of this study is to evaluate the supplementation of omega-3, omega-6 or omega-9 on the cardiovascular risk of adult individuals. For this, we recruited 240 subjects with cardiovascular risk, classified according to the Framingham risk score. These individuals will be assigned to groups: W-3 (n = 80, 3.0 g/d of fish oil), W-6 (n = 80, 3.0 g/d of sunflower oil - source of omega 6), W-9 (n = 80, 3.0 g/d of olive oil - source of omega 9). At baseline, 4 and 8 weeks will be assessed the acute effect of interventions on the following parameters: lipid profile and apolipoproteins, size of LDL and HDL, lipid-soluble antioxidants, PON1, oxidation products [LDL (-), anti-LDL (- )], inflammatory markers (CRP, IL-6 and TNF-±), Lp-PLA2, nefas, CETP and glucose metabolism (glucose and insulin). Are also monitored the clinical, family history of diseases, food intake, physical activity level and anthropometric parameters. Adherence to the intervention will be evaluated using a structured questionnaire and biochemical markers. The development objective of the present study the following outcomes: Primary - structural modification of LDL and HDL, cardiometabolic and oxidative markers. Secondary - modification of the lipid profile, glucose metabolism, body composition and anthropometry. (AU) | |