| Full text | |
| Author(s): |
Januario, Yunan C.
;
daSilva, Luis L. P.
Total Authors: 2
|
| Document type: | Journal article |
| Source: | NATURE STRUCTURAL & MOLECULAR BIOLOGY; v. 27, n. 9, p. 3-pg., 2020-08-19. |
| Abstract | |
The cell surface protein CD4 acts as a coreceptor for incoming HIV particles. However, the expression of CD4 in HIV-producing cells is detrimental to virus propagation and pathogenicity. To solve this issue, the viral accessory protein Nef forces CD4 endocytosis and targets it for lysosomal degradation. Structural elucidation of the AP-2-Nef-CD4 complex shows how Nef connects CD4 to the clathrin endocytic machinery, revealing a potential new target for anti-HIV therapy. (AU) | |
| FAPESP's process: | 18/00297-7 - Study of the effects of HIV-1 Nef on the host-cell endomembrane system and their implications in viral pathogenesis |
| Grantee: | Luis Lamberti Pinto da Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/12022-0 - Characterization of the molecular mechanisms used by Arc protein to modify the intracellular traffic and processing of AMPA receptors and beta-amyloid precursor protein (APP) |
| Grantee: | Yunan Costa Januário |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/02418-9 - Molecular mechanisms of Oropouche Virus assembly |
| Grantee: | Luis Lamberti Pinto da Silva |
| Support Opportunities: | Regular Research Grants |