Role of spinal neurons in the maintenance of elevated sympathetic activity: a novel therapeutic target?

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Author(s):	Milanez, Maycon I. O. ; Nishi, Erika E. ; Bergamaschi, Cassia T. ; Campos, Ruy R. Total Authors: 4
Document type:	Journal article
Source:	AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 319, n. 3, p. 6-pg., 2020-09-01.
Abstract
The control of sympathetic vasomotor activity involves a complex network within the brain and spinal circuits. An extensive range of studies has indicated that sympathoexcitation is a common feature in several cardiovascular diseases and that strategies to reduce sympathetic vasomotor overactivity in such conditions can be beneficial. In the present mini-review, we present evidence supporting the spinal cord as a potential therapeutic target to mitigate sympathetic vasomotor overactivity in cardiovascular diseases, focusing mainly on the actions of spinal angiotensin II on the control of sympathetic preganglionic neuronal activity. (AU)

FAPESP's process:	18/02671-3 - Functional and molecular actions of renal nerve in experimental chronic renal failure
Grantee:	Cassia Marta de Toledo Bergamaschi
Support Opportunities:	Regular Research Grants


FAPESP's process:	18/01898-4 - Evaluation of brain-spinal projections in the temporal establishment of renal sympathetic hyperactivation in Renovascular Hypertension
Grantee:	Maycon Igor de Oliveira Milanez
Support Opportunities:	Scholarships in Brazil - Doctorate