From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential

Author(s)

Alves, Maira Bianchi Rodrigues ; Celeghini, Eneiva Carla Carvalho ; Belleannee, Clemence

• Document type: Journal article
• Source: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 8, p. 16-pg., 2020-08-21.

Abstract

In addition to the paternal genome, spermatozoa carry several intrinsic factors, including organelles (e.g., centrioles and mitochondria) and molecules (e.g., proteins and RNAs), which are involved in important steps of reproductive biology such as spermatogenesis, sperm maturation, oocyte fertilization and embryo development. These factors constitute potential biomarkers of "viable sperm" and male fertility status and may become major assets for diagnosing instances of idiopathic male infertility in both humans and livestock animals. A better understanding of the mechanism of action of these sperm intrinsic factors in the regulation of reproductive and developmental processes still presents a major challenge that must be addressed. This review assembles the main data regarding morpho-functional and intrinsic sperm features that are associated with male infertility, with a particular focus on microRNA (miRNA) molecules. (AU)

• FAPESP's process: 15/09154-6 - Profile of microRNAs present in semen and embryos and their relationship to fertility
• Grantee: Maíra Bianchi Rodrigues Alves
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/05395-1 - Bull semen and embryos microRNAs profile and these correlation with fertility
• Grantee: Eneiva Carla Carvalho Celeghini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/23243-4 - MicroRNA profile analysis in human and mice sperm collected from different regions of the reproductive tract
• Grantee: Maíra Bianchi Rodrigues Alves
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate