Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF-7 Breast Cancer Cell Line

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Author(s):	Roberto de Souza, Anderson ; Stefany de Souza Castro, Mona ; Olimpio de Souza, Thiago ; Cassio Sola Veneziani, Rodrigo ; Kenupp Bastos, Jairo ; Ricardo Ambrosio, Sergio ; Alves dos Santos, Raquel Total Authors: 7
Document type:	Journal article
Source:	CHEMISTRYSELECT; v. 5, n. 38, p. 4-pg., 2020-10-15.
Abstract
Breast cancer continues to be the major cause of cancer death among women. The high genetic heterogeneity and chemoresistant phenotypes of breast tumors require the search for new compounds to expand the options for the treatment of this disease. Kaurenoic acid (KA) is anent-kaurane type-diterpene with cytotoxic and genotoxic effects against gastric and cervical cancer cells. In the present study, we report the antiproliferative effects of KA in the breast tumoral cell line MCF-7 and the normal breast counterpart MCF-10 A. The long-term cytotoxic effects of KA were observed by the reduction of survival fraction at 50 and 100 mu M. At these concentrations, the treatment with KA increased the extension of DNA damage followed by G1 cell cycle phase accumulation and induction of apoptosis in both cell lines. Taken together, the results contained herein support the promising antiproliferative effects of KA. (AU)

FAPESP's process:	11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species
Grantee:	Jairo Kenupp Bastos
Support Opportunities:	Research Projects - Thematic Grants