Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne-azide cycloaddition

Stefani, Helio A.; Canduzini, Hugo A.; Manarin, Flavia

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne-azide cycloaddition

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Author(s):	Stefani, Helio A. ^[1] ; Canduzini, Hugo A. ^[1] ; Manarin, Flavia ^[1] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Dept Farm, Fac Ciencias Farmaceut, BR-05508 Sao Paulo - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	Tetrahedron Letters; v. 52, n. 46, p. 6086-6090, NOV 16 2011.
Web of Science Citations:	18
Abstract
The synthesis of 1,2,3-triazoles was developed employing sequential copper azide-alkyne cycloaddition, tosylation, sodium azide, and copper azide-alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

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