| Full text | |
| Author(s): |
Occhiutto, Marcelo Luis
;
de Melo, Monica Barbosa
;
Cabral de Vasconcellos, Jose Paulo
;
Rosa Rodrigues, Thiago Adalton
;
Bajano, Flavia Fialho
;
Costa, Fernando Ferreira
;
Costa, Vital Paulino
Total Authors: 7
|
| Document type: | Journal article |
| Source: | OPHTHALMIC GENETICS; v. 42, n. 1, p. 9-pg., 2020-12-09. |
| Abstract | |
Background: Primary open-angle glaucoma (POAG) is a multifactorial disease that affects 65.5 million people worldwide. In addition to the genetic variants already established as indicators of greater risk for POAG, the apolipoprotein (APOE) gene has been studied in some populations, with controversial results. The aim of this study is to investigate the frequency of the genetic variants of APOE in the Brazilian population, and to evaluate the association between these polymorphisms and the risk of POAG. Methods: APOE variants (rs429358; rs7412) were genotyped in 402 POAG patients and 401 controls. We evaluated the association between APOE genetic variants and the risk for POAG, as well as the correlation between the requirement of glaucoma surgery and the APOE polymorphisms. Results: Among the three APOE gene isoforms, we found a low frequency of APOE alleles epsilon 2 (7.34%) and epsilon 4 (11.76%), but a high frequency of epsilon 3 (80.88%) in our population. When compared to epsilon 3 epsilon 3 reference genotype, epsilon 2 allele-carriers (OR = 1.516; p-value = 0.04) and epsilon 2 epsilon 3 genotype (OR = 1.655; p-value = 0.02) were associated with a greater risk for POAG. An additive genetic model confirmed the influence of the epsilon 2 allele in the risk of POAG in this sample of the Brazilian population (OR = 1.502; p-value = 0.04). There was no significant association between the analyzed genotypes and the requirement or number of glaucoma surgeries (p > .05). Conclusion: Brazilian individuals carrying the APOE epsilon 2 allele may be at an increased risk for the development of POAG. (AU) | |
| FAPESP's process: | 10/18353-9 - Inflammatory cytokines and their association with treatment and etiology of primary open angle glaucoma |
| Grantee: | Mônica Barbosa de Melo |
| Support Opportunities: | Regular Research Grants |