| Full text | |
| Author(s): |
Ribeiro, I. R. S.
;
da Silva, R. F.
;
Silveira, C. P.
;
Galdino, F. E.
;
Cardoso, M. B.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | NANO TODAY; v. 36, p. 4-pg., 2021-02-01. |
| Abstract | |
The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effective-driven fashion. This interaction is enhanced by a meticulous spatial arrangement which results in a quasi-crystalline distribution of proteins on the viruses' surface. Amidst the COVID-19 pandemic, we propose to look at the SARS-CoV-2 nanoscale viral scaffold as an example of a highly-ordered architecture that must inspire and tailor the production of targeted synthetic nanoparticles. (C) 2020 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles |
| Grantee: | Watson Loh |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/09555-9 - Influence of protein corona on interaction and internalization of silica nanoparticles in human cells: from two-dimensional to tri-dimensional images |
| Grantee: | Flávia Elisa Galdino |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/14007-3 - Double-functionalised silica nanoparticles for anti-bacterial effect |
| Grantee: | Camila Pedroso Silveira Bueno |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |