Cashew Gum Polysaccharide Nanoparticles Grafted with Polypropylene Glycol as Carriers for Diclofenac Sodium

Author(s)

da Silva, Cassio Nazareno Silva ; Di-Medeiros, Maria Carolina Bezerra ; Liao, Luciano Morais ; Fernandes, Katia Flavia ; Batista, Karla de Aleluia

• Document type: Journal article
• Source: MATERIALS; v. 14, n. 9, p. 17-pg., 2021-05-01.

Abstract

This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 mu L of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of -5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium. (AU)

• FAPESP's process: 19/16135-9 - National Institute of Science and Technology for the biorational control of pest-insect and phytopathogens
• Grantee: Maria Carolina Bezerra di Medeiros Leal
• Support Opportunities: Scholarships in Brazil - Post-Doctoral