| Full text | |
| Author(s): Show less - |
Garibaldi, Pedro M. M.
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Oliveira, Luciana C.
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da Fonseca, Benedito A.
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Martins, Maria A.
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Miranda, Carlos H.
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Almado, Carlos E. L.
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Langhi, Dante M.
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Gilio, Renato N.
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Palma, Leonardo C.
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Gomes, Bruno B. M.
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Bottura, Camila
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Barrientto, Larissa C.
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Donadel, Camila D.
;
Calado, Rodrigo T.
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De Santis, Gil C.
Total Authors: 15
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| Document type: | Journal article |
| Source: | Transfusion Medicine; v. 32, n. 3, p. 4-pg., 2021-06-03. |
| Abstract | |
Objectives Evaluate the impact of ABO histo-blood group type on COVID-19 severity. Background ABO histo-blood type has been associated with different outcomes in infectious diseases. It has also shown a higher proportion of type A patients with SARS-CoV-2. In this observational study, extracted from an ongoing clinical trial on the efficacy of convalescent plasma transfused in COVID-19 patients, we describe the impact of ABO blood type on the risk of developing severe COVID-19. Materials and Methods Seventy-two consecutive patients (37 type A, 23 type O, 11 type B, 1 type AB) with severe (respiratory failure) COVID-19 were included. Control group was composed of 160 individuals randomly selected from the same populational basis. Results Blood group A was overrepresented (51.39%) in the patient group in relation to the control group (30%), whereas blood group O was less represented (31.94%) in patient than in control group (48%). Odds ratio (A vs. O) was 2.581 (1.381-4.817), CI 95%; p = 0.004. Also, blood group A patients appeared to have more severe disease, given by the scores of the Sequential Organ Failure Assessment and Simplified Acute Physiologic Score 3 (p = 0.036 and p = 0.058, respectively). Conclusion Histo-blood type A is associated with a higher risk of developing severe COVID-19 in relation to blood type O. (AU) | |
| FAPESP's process: | 20/05367-3 - Convalescent donor plasma to treat patients with severe SARS-CoV-2 infection (COVID-19) |
| Grantee: | Rodrigo do Tocantins Calado de Saloma Rodrigues |
| Support Opportunities: | Regular Research Grants |