Down syndrome in COVID-19: an observational study of the first year of the pandemic in Brazil

• Grant number: 21/05810-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2021
• End date: January 31, 2023
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Fernando Augusto de Lima Marson
• Grantee: Matheus Negri Boschiero
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Introduction: Few studies have described that COVID-19 in patients with Down Syndrome (DS) is associated with longer intubation time and higher mortality rates, however, most of these studies have their conclusions based on a small sample size. In this context, due to the low sample size, the real impact of the COVID-19 has on DS patients still needs to be better clarified. Therefore, the primary objective of the present study is to evaluate, in a cohort in Brazil, the relative risk for death of patients with DS and COVID-19 when compared with individuals with Severe Acute Respiratory Syndrome (SARS) due to COVID-19 or other etiologic factors. Methods: In the study will be performed an epidemiological analysis of markers available in OpenDataSUS of patients who were diagnosed with SARS in the period between March 2020 and March 2021, that is, one year of the COVID-19 pandemic. Study participants will be divided into 4 groups such as: (G1) participants diagnosed with DS and who were positive for COVID-19; (G2) participants diagnosed with DS and who were not positive for COVID-19 (SARS due to etiological factors other than SARS-CoV-2 infection); (G3) participants with COVID-19 and without DS and/or other comorbidities; (G4) participants diagnosed with SARS due to etiological factors other than SARS-CoV-2 infection and who have not been diagnosed with DS and/or other comorbidities. In the study, the primary outcome will be the analysis of mortality between the different groups described above and the secondary will be: (i) to analysis of mortality according to the need for invasive mechanical ventilation (IMV), hospitalization and admission to the intensive care unit (ICU) for the different groups evaluated; (ii) to analysis of the profile of clinical symptoms between G1 and G2 groups - to describe how COVID-19 can differentiate the clinical presentation from SARS by other factors in DS; (iii) to analysis of the profile of clinical symptoms between groups G1 and G3 - to describe how DS patients are responsive in symptomatology compared to other patients with COVID-19; and finally, (iv) to compare the prevalence of symptoms and comorbidities among individuals in G1 according to the outcome (death and clinical recovery) in order to denote the presence of clinical markers (symptoms and morbidities) with the risk of death due to COVID-19. Expected Results: It is expected that: (i) patients in G1 have worse outcomes (mortality, hospitalization, need for IMV and admission to the ICU) than the other groups; (ii) it is possible to clinically differentiate G1 from G2, and that G1 had symptoms related to worse severity; (iii) it is possible to clinically differentiate G1 from G3 and that G1 had symptoms related to worse severity; (iv) it is possible to predict mortality due to COVID-19 of patients in G1 based on clinical symptoms and comorbidities. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANSONE, NATHALIA M. S.; BOSCHIERO, MATHEUS N.; ORTEGA, MANOELA M.; RIBEIRO, ISADORA A.; PEIXOTO, ANDRESSA O.; MENDES, ROBERTO T.; MARSON, FERNANDO A. L.. Severe Acute Respiratory Syndrome by SARS-CoV-2 Infection or Other Etiologic Agents Among Brazilian Indigenous Population: An Observational Study from the First Year of Coronavirus Disease (COVID)-19 Pandemic. LANCET REGIONAL HEALTH-AMERICAS, v. 8, p. 23-pg., 2022-01-07. (21/05810-7)

BOSCHIERO, MATHEUS NEGRI; LUTTI FILHO, JOSE ROBERTO; ORTEGA, MANOELA MARQUES; MARSON, FERNANDO AUGUSTO LIMA. High case fatality rate in individuals with Down syndrome and COVID-19 in Brazil: a two-year report. Journal of Clinical Pathology, v. N/A, p. 4-pg., 2022-06-28. (21/05810-7)

SANSONE, NATHALIA MARIANA SANTOS; BOSCHIERO, MATHEUS NEGRI; MARSON, FERNANDO AUGUSTO LIMA. Epidemiologic Profile of Severe Acute Respiratory Infection in Brazil During the COVID-19 Pandemic: An Epidemiological Study. FRONTIERS IN MICROBIOLOGY, v. 13, p. 24-pg., 2022-07-01. (21/05810-7)

BOSCHIERO, MATHEUS NEGRI; CAPASSO PALAMIM, CAMILA VANTINI; LIMA MARSON, FERNANDO AUGUSTO. The hindrances to perform the COVID-19 vaccination in Brazil. HUMAN VACCINES & IMMUNOTHERAPEUTICS, v. 17, n. 11, AUG 2021. (21/05810-7)

SANSONE, NATHALIA M. S.; BOSCHIERO, MATHEUS N.; VALENCISE, FELIPE E.; PALAMIM, CAMILA V. C.; MARSON, FERNANDO A. L.. Characterization of demographic data, clinical signs, comorbidities, and outcomes according to the race in hospitalized individuals with COVID-19 in Brazil: An observational study. OURNAL OF GLOBAL HEALT, v. 12, p. 20-pg., 2022-01-01. (21/08437-5, 21/05810-7)

SANTOS SANSONE, NATHALIA MARIANA; PEREIRA, LETICIA ROGINI; BOSCHIERO, MATHEUS NEGRI; VALENCISE, FELIPE EDUARDO; ALEXANDRE FRAGA, ANDREA MELO; LIMA MARSON, FERNANDO AUGUSTO. Characterization of Clinical Features of Hospitalized Patients Due to the SARS-CoV-2 Infection in the Absence of Comorbidities Regarding the Sex: An Epidemiological Study of the First Year of the Pandemic in Brazil. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 15, p. 20-pg., 2022-08-01. (21/08437-5, 21/05810-7)

PALAMIM, CAMILA VANTINI CAPASSO; BOSCHIERO, MATHEUS NEGRI; VALENCISE, FELIPE EDUARDO; MARSON, FERNANDO AUGUSTO LIMA. Human Development Index Is Associated with COVID-19 Case Fatality Rate in Brazil: An Ecological Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 9, p. 21-pg., 2022-05-01. (21/08437-5, 21/05810-7)

BOSCHIERO, MATHEUS NEGRI; DUARTE, AIRES; CAPASSO PALAMIM, CAMILA VANTINI; ALVAREZ, ALFONSO EDUARDO; MAUCH, RENAN MARRICHI; LIMA MARSON, FERNANDO AUGUSTO. requency of respiratory pathogens other than SARS-CoV-2 detected COVID-1. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 102, n. 2, FEB 2022. (21/05810-7)

BOSCHIERO, MATHEUS NEGRI; CAPASSO PALAMIM, CAMILA VANTINI; ORTEGA, MANOELA MARQUES; LIMA MARSON, FERNANDO AUGUSTO. Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil. Human Genetics, v. 141, n. 12, p. 18-pg., 2022-06-28. (21/05810-7)

MARQUES, LEONARDO SOUZA; BOSCHIERO, MATHEUS NEGRI; SANSONE, NATHALIA MARIANA SANTOS; BRIENZE, LETICIA RULLI; MARSON, FERNANDO AUGUSTO LIMA. Epidemiological Profile of Hospitalized Patients with Cystic Fibrosis in Brazil Due to Severe Acute Respiratory Infection during the COVID-19 Pandemic and a Systematic Review of Worldwide COVID-19 in Those with Cystic Fibrosis. HEALTHCARE, v. 11, n. 13, p. 39-pg., 2023-07-01. (21/05810-7)

PALAMIM, CAMILA VANTINI CAPASSO; BOSCHIERO, MATHEUS NEGRI; MARSON, FERNANDO AUGUSTO LIMA. Epidemiological profile and risk factors associated with death in patients receiving invasive mechanical ventilation in an adult intensive care unit from Brazil: a retrospective study. FRONTIERS IN MEDICINE, v. 10, p. 14-pg., 2023-04-25. (21/05810-7)