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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Full text
Author(s):
L.B. Razza ; M.A. Vanderhasselt ; M.S. Luethi [3] ; J. Repple ; G. Busatto [5] ; C.A. Buchpiguel [6] ; A.R. Brunoni ; P.H.R. da Silva
Total Authors: 8
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 56, 2023-10-20.
Abstract

Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickness of regions of interest was associated with working memory performance after NIBS by performing a secondary analysis of previously published research. Structural magnetic resonance imaging data were analyzed from healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), and placebo. Twenty-two participants were randomly assigned to receive all the interventions in a random order. The working memory task was conducted after the end of each NIBS session. Regions of interest were the bilateral DLPFC, medial prefrontal cortex, and posterior cingulate cortex. Overall, 66 NIBS sessions were performed. Findings revealed a negative significant association between cortical thickness of the bilateral dorsolateral prefrontal cortex and reaction time for both tDCS (left: P=0.045, right: P=0.037) and iTBS (left: P=0.007, right: P=0.007) compared to placebo. A significant positive association was found for iTBS and posterior cingulate cortex (P=0.03). No association was found for accuracy. Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with working memory performance following different NIBS interventions. Therefore, cortical thickness could explain - to some extent - the heterogeneous effects of NIBS probing the DLPFC. (AU)

FAPESP's process: 19/07256-7 - Cerebral alteration perfusion induced by transcranial stimulation of the prefrontal cortex: a randomized, placebo-controlled study, using 99mTc SPECT
Grantee:Lais Boralli Razza
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 22/03266-0 - Investigation of neuroimaging assessments and current flow modeling as target engagement and predictor biomarkers of convulsive therapies
Grantee:Pedro Henrique Rodrigues da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/06009-6 - Non-implantable neuromodulation therapies: a perspective for the depressed brain
Grantee:Andre Russowsky Brunoni
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/10861-7 - A Phase-I bilateral project using a sham-controlled, factorial design of transcranial direct current stimulation and theta-burst stimulation to investigate the effects on multimodal assessments of prefrontal cortex functioning
Grantee:Andre Russowsky Brunoni
Support Opportunities: Regular Research Grants
FAPESP's process: 21/10574-0 - Prognostic enhancement in depressed patients on different non-implantable neuromodulation interventions
Grantee:Matthias Stephan Luthi
Support Opportunities: Scholarships in Brazil - Post-Doctoral