Intravital Microscopy Evidence That Methylene Blue Should Be a Vasopressor-Sparing Agent in Sepsis Vasoplegia

Author(s)

Fabiola Leslie Antunes Cardoso Mestriner ^[1] ; Pedro Brüch Dantas ^[2] ; Jéssyca Michelon Barbosa ^[3] ; Paulo Roberto B. Evora ^[4] ; Christiane Becari

Affiliation

^[1] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy - Brasil

^[2] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy - Brasil

^[3] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy - Brasil

^[4] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Department of Surgery and Anatomy - Brasil

• Document type: Journal article
• Source: Revista Brasileira de Cirurgia Cardiovascular; v. 39, n. 3 2024-04-05.

Abstract

ABSTRACT Microvasculature failure is expected in sepsis and at higher amine concentrations. Therefore, special attention focused individually on microcirculation is needed. Here, we present that methylene blue can prevent leukocytes from adhering to the endothelium in a rat model of lipopolysaccharide-induced endotoxemia. As hypothesis evidence, an intravital microscopy image is presented. (AU)

• FAPESP's process: 19/21721-4 - Biochemical and molecular analysis of the renin-angiotensin system (RAS) components in the pathophysiology of abdominal aortic aneurysm (AAA) in patients undergoing AAA correction surgery at HCRP-USP
• Grantee: Jéssyca Michelon Barbosa
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/23718-8 - Role of renin angiotensin system in abdominal aortic aneurysm
• Grantee: Christiane Becari
• Support Opportunities: Scholarships in Brazil - Young Researchers