| Full text | |
| Author(s): |
Gabriela C. Brêda
;
Alexandre S. França
[2]
;
Kleber T. de Oliveira
[3]
;
Rodrigo V. Almeida
[4]
;
Rodrigo O. M. A. de Souza
[5]
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 35, n. 8 2024-03-22. |
| Abstract | |
In this study, we describe a light-driven photocatalytic decarboxylation of palmitic acid and related fatty acids using Chlorella variabilis fatty acid photodecarboxylase (CvFAP). By utilizing violet light emitting diode (LED) light (50 W; 397 nm), we achieved a remarkable conversion efficiency of 99% within just 4 min, surpassing the previous 79% conversion achieved in 60 min using blue LED light (300 W; 439 nm). Importantly, the use of 50 W violet LED light also resulted in a lower enzyme photoinactivation rate when compared to 300 W blue LED. Comparing the whole-cell biocatalyst with the enzymatic extract, we found that the former demonstrated superior catalytic performance and reduced susceptibility to photoinactivation. Furthermore, whole-cell biocatalyst reuse was demonstrated after five sequential batches. Employing this approach, we successfully synthesized 26 mmol L-1 h-1 of pentadecane, showcasing a promising strategy to improve productivity. These findings represent a significant advancement in CvFAP photodecarboxylation processes compared to the literature, utilizing an alternative light source, with potential implications to the biofuel sector. (AU) | |
| FAPESP's process: | 19/27176-8 - Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/06874-6 - Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs |
| Grantee: | Kleber Thiago de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07276-1 - CEPOF - Optics and Photonic Research Center |
| Grantee: | Vanderlei Salvador Bagnato |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |