| Full text | |
| Author(s): |
Teixeira-Fonseca, Jorge Lucas
;
Souza, Diego Santos
;
Conceicao, Michael Ramon de Lima
;
Marques, Leisiane Pereira
;
Durco, Aimee Obolari
;
da Silva, Polyana Leal
;
Joviano-Santos, Julliane V.
;
Santos-Miranda, Artur
;
Roman-Campos, Danilo
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Food and Chemical Toxicology; v. 187, p. 12-pg., 2024-04-04. |
| Abstract | |
Tebuconazole (TEB), a widely used pesticide in agriculture to combat fungal infections, is commonly detected in global food, potable water, groundwater, and human urine samples. Despite its known in vivo toxicity, its impact on heart function remains unclear. In a 28-day study on male Wistar rats (approximately 100 g), administering 10 mg/kg/day TEB or a vehicle (control) revealed no effect on body weight gain or heart weight, but an increase in the infarct area in TEB-treated animals. Notably, TEB induced time-dependent changes in in vivo electrocardiograms, particularly prolonging the QT interval after 28 days of administration. Isolated left ventricular cardiomyocytes exposed to TEB exhibited lengthened action potentials and reduced transient outward potassium current. TEB also increased reactive oxygen species (ROS) production in these cardiomyocytes, a phenomenon reversed by N-acetylcysteine (NAC). Furthermore, TEB-treated animals, when subjected to an in vivo dobutamine (Dob) and caffeine (Caf) challenge, displayed heightened susceptibility to severe arrhythmias, a phenotype prevented by NAC. In conclusion, TEB at the no observed adverse effect level (NOAEL) dose adversely affects heart electrical function, increases arrhythmic susceptibility, partially through ROS overproduction, and this phenotype is reversible by scavenging ROS with NAC. (AU) | |
| FAPESP's process: | 22/14133-1 - Molecular mechanisms of increased susceptibility to cardiac arrhythmias due to chronic in vivo exposure to low doses of triazole pesticides: implications for worsening heart disease caused by Pulmonary Hypertension |
| Grantee: | Jorge Lucas Teixeira da Fonseca |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 21/05584-7 - Assessment of acute and chronic toxicity of the heart and brain exposed to pesticides found in potable water in Brazil |
| Grantee: | Danilo Roman Campos |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 20/14635-1 - Modeling of monogenic diseases for physiopathological studies and pharmacological tests using specialized cells derived from iPSCs |
| Grantee: | João Bosco Pesquero |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/15122-0 - CARDIOTOXICITY INDUCED BY THE PESTICIDE TEBUCONAZOLE IN MICE: FROM CONCEPTION TO ADULT LIFE |
| Grantee: | Leisiane Pereira Marques |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 23/11912-2 - Pesticide as an enhancement factor for Doxorubicin-induced cardiotoxicity |
| Grantee: | Aimée Obolari Durço |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |