Enteroendocrine cells and gut hormones as potential targets in the crossroad of the gut-kidney axis communication

Author(s)

Neto, Jose Arimatea de Oliveira Nery ; Yariwake, Victor Yuji ; Camara, Niels Olsen Saraiva ; Andrade-Oliveira, Vinicius

• Document type: Journal article
• Source: FRONTIERS IN PHARMACOLOGY; v. 14, p. 20-pg., 2023-10-19.

Abstract

Recent studies suggest that disruptions in intestinal homeostasis, such as changes in gut microbiota composition, infection, and inflammatory-related gut diseases, can be associated with kidney diseases. For instance, genomic investigations highlight how susceptibility genes linked to IgA nephropathy are also correlated with the risk of inflammatory bowel disease. Conversely, investigations demonstrate that the use of short-chain fatty acids, produced through fermentation by intestinal bacteria, protects kidney function in models of acute and chronic kidney diseases. Thus, the dialogue between the gut and kidney seems to be crucial in maintaining their proper function, although the factors governing this crosstalk are still emerging as the field evolves. In recent years, a series of studies have highlighted the significance of enteroendocrine cells (EECs) which are part of the secretory lineage of the gut epithelial cells, as important components in gut-kidney crosstalk. EECs are distributed throughout the epithelial layer and release more than 20 hormones in response to microenvironment stimuli. Interestingly, some of these hormones and/or their pathways such as Glucagon-Like Peptide 1 (GLP-1), GLP-2, gastrin, and somatostatin have been shown to exert renoprotective effects. Therefore, the present review explores the role of EECs and their hormones as regulators of gut-kidney crosstalk and their potential impact on kidney diseases. This comprehensive exploration underscores the substantial contribution of EEC hormones in mediating gut-kidney communication and their promising potential for the treatment of kidney diseases. (AU)

• FAPESP's process: 21/03913-3 - Influence of obesity on the mechanisms of peripheral tolerance and on the modulation of immune response in the small intestine of mice.
• Grantee: Victor Yuji Yariwake
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/14755-0 - Shaping gut microbiota and immune system by the intestinal epithelial cells: from tissue homeostasis to diseases
• Grantee: Vinicius de Andrade Oliveira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 22/08362-8 - Biology of enteroendocrine cells in homeostasis and during intestinal inflammation
• Grantee: José Arimatéa Oliveira Nery Neto
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)