| Full text | |
| Author(s): |
Rizoli, Cintia
;
dos Santos, Nathalia Medina
;
Marostica Junior, Mario Roberto
;
da Cruz-Hofling, Maria Alice
;
Mendonca, Monique Culturato Padilha
;
de Jesus, Marcelo Bispo
Total Authors: 6
|
| Document type: | Journal article |
| Source: | Nanotechnology; v. 36, n. 2, p. 12-pg., 2025-01-13. |
| Abstract | |
Reduced graphene oxide (rGO) has unique physicochemical properties that make it suitable for therapeutic applications in neurodegenerative scenarios. This study investigates the therapeutic potential of rGO in a cuprizone-induced demyelination model in mice through histomorphological techniques and analysis of biochemical parameters. We demonstrate that daily intraperitoneal administration of rGO (1 mg ml-1) for 21 days tends to reduce demyelination in the Corpus callosum by decreasing glial cell recruitment during the repair mechanism. Additionally, rGO interferes with oxidative stress markers in the brain and liver indicating potential neuroprotective effects in the central nervous system. No significant damage to vital organs was observed, suggesting that multiple doses could be used safely. However, further long-term investigations are needed to understand rGO distribution, metabolism, routes of action and associated challenges in central neurodegenerative therapies. Overall, these findings contribute to the comprehension of rGO effects in vivo, paving the way for possible future clinical research. (AU) | |
| FAPESP's process: | 23/06143-0 - Molecular aspects of the nano-cell interactions: therapeutic activity, delivery of oligonucleotides and nanotoxicity |
| Grantee: | Marcelo Bispo de Jesus |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/01218-3 - Evaluating the nanotoxicity using image-based multiparametric single-cell profiling |
| Grantee: | Marcelo Bispo de Jesus |
| Support Opportunities: | Regular Research Grants |