Antileishmanial and Antifungal Activities of Volatile Oils from Cinnamomum Cassia Bark and Schinus Molle Leaves

Author(s)

da Silva, Aternoskaires S. R. ; Fernandes, Cassia C. ; dos Santos, Daiane A. ; Mazza, Marya C. M. ; Silva, Jackson B. A. ; Magalhaes, Lizandra G. ; Pires, Regina H. ; Miranda, Mayker L. D. ; Crotti, Antonio E. M.

• Document type: Journal article
• Source: CHEMISTRY & BIODIVERSITY; v. 21, n. 9, p. 7-pg., 2024-08-08.

Abstract

This study reports on the chemical composition and antileishmanial and anticandidal activities of volatile oils (VOs) of Schinus molle dried leaves (SM), Cinnamomum cassia branch bark (CC) and their blends. Major constituents of SM were spathulenol (26.93 %), beta-caryophyllene (19.90 %), and caryophyllene oxide (12.69 %), whereas (E)-cinnamaldehyde (60.11 %), cinnamyl acetate (20.90 %) and cis-2-methoxycinnamic acid (10.37 %) were predominant in CC. SM (IC50=21.45 mu g/mL) and CC (IC50=23.27 mu g/mL) displayed good activity against L. amazonensis promastigotes, besides having good or moderate activity against nine Candida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 mu g/mL. While the three SM and CC blends were not more active than the VOs tested individually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 mu g/mL, which is very similar to the IC50 of amphotericin B (positive control). (AU)

• FAPESP's process: 07/54241-8 - Prospecção de óleos essenciais de espécies brasileiras cultiváveis com atividade contra patógenos da cavidade bucal
• Grantee: Antônio Eduardo Miller Crotti
• Support Opportunities: BIOTA-FAPESP Program - Young Investigators Grants