Continuous flow reactions in the preparation of active pharmaceutical ingredients and fine chemicals

Author(s)

Martins, Guilherme M. ; Braga, Felipe C. ; de Castro, Pedro P. ; Brocksom, Timothy J. ; de Oliveira, Kleber T.

• Document type: Journal article
• Source: CHEMICAL COMMUNICATIONS; v. 60, n. 24, p. 14-pg., 2024-02-29.

Abstract

Herein, we present an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation of active pharmaceutical ingredients (APIs) and fine chemical intermediates. Examples highlighting the benefits and challenges associated with continuous flow processes, mainly involving continuous thermal, photo- and electrochemical transformations, are drawn from the relevant literature, especially our experience and collaborations in this area, with emphasis on the synthesis and prospective scale-up. This feature article presents an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation of active pharmaceutical ingredients (APIs) and fine chemical intermediates. (AU)

• FAPESP's process: 23/04020-8 - APIs synthesis using enabling technologies: approaches involving electrosynthesis and photocatalysis under continuous flow conditions
• Grantee: Kleber Thiago de Oliveira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/00074-3 - Regioselective fluorination of N-heterocycles using electrosynthesis and continuous flow conditions
• Grantee: Guilherme Ariel Machado Martins
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06110-9 - Application of continuous flow chemistry in the synthesis of Active Pharmaceutical Ingredients (APIs): cannabidiol, fentanyl, and ibuprofen
• Grantee: Felipe Camargo Braga
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/13924-2 - Development of novel continuous flow approaches towards the preparation of pharmaceuticals: Axitinib, Lacosamide, Pioglitazone and Rosiglitazone
• Grantee: Pedro Pôssa de Castro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral