MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training

Author(s)

Improta-Caria, Alex Cleber ; Rodrigues, Luis Felipe ; Joaquim, Victor Hugo Antonio ; De Sousa, Ricardo Augusto Leoni ; Fernandes, Tiago ; Oliveira, Edilamar Menezes

• Document type: Journal article
• Source: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 326, n. 3, p. 14-pg., 2024-03-08.

Abstract

Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity develop long-term fibrotic processes in the heart, promoting pathological cardiac remodeling, including after myocardial infarction, reparative fibrotic processes also occur. These processes are regulated by many intracellular signaling pathways that have not yet been completely elucidated, including those associated with microRNA (miRNA) expression. miRNAs are small RNA transcripts (18-25 nucleotides in length) that act as posttranscriptionally regulators of gene expression, inhibiting or degrading one or more target messenger RNAs (mRNAs), and proven to be involved in many biological processes such as cell cycle, differentiation, proliferation, migration, and apoptosis, directly affecting the pathophysiology of several diseases, including cardiac fibrosis. Exercise training can modulate the expression of miRNAs and it is known to be beneficial in various cardiovascular diseases, attenuating cardiac fibrosis processes. However, the signaling pathways modulated by the exercise associated with miRNAs in cardiac fibrosis were not fully understood. Thus, this review aims to analyze the expression of miRNAs that modulate signaling pathways in cardiac fibrosis processes that can be regulated by exercise training. (AU)

• FAPESP's process: 21/06229-6 - Effect of the association between arterial hypertension and Walker-256 cancer on the cardiac phenotype and tumor progression: therapeutic potential of aerobic exercise training
• Grantee: Luis Felipe Rodrigues
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 22/03138-2 - Functions and regulatory mechanisms of lincRNA-p21 in skeletal muscle: role on stem cell fate, myogenesis, trophism, contractility, exercise performance and injury repair
• Grantee: Tiago Fernandes
• Support Opportunities: Research Grants - Initial Project
• FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
• Grantee: Carlos Eduardo Negrão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/22579-4 - Exosomal microRNAs as circulating biomarkers and mediators of the cardioprotective effect in patients undergoing cancer therapies
• Grantee: Edilamar Menezes de Oliveira
• Support Opportunities: Regular Research Grants