| Full text | |
| Author(s): |
Cedrola, Franciane
;
Senra, Marcus Vinicius Xavier
;
Morales, Millke Jasmine Arminini
;
Fregulia, Priscila
;
Canesin, Lucas
;
Dias, Roberto Junio Pedroso
;
Solferini, Vera Nisaka
Total Authors: 7
|
| Document type: | Journal article |
| Source: | MICROBIAL GENOMICS; v. 10, n. 7, p. 12-pg., 2024-07-01. |
| Abstract | |
Several hundred ciliate species live in animals' guts as a part of their microbiome. Among them, Muniziella cunhai (Trichostomatia, Pycnotrichidae), the largest described ciliate, is found exclusively associated with Hydrochoerus hydrochaeris (capybara), the largest known rodent reaching up to 90 kg. Here, we present the sequence, structural and functional annotation of this giant microeukaryote macronuclear genome and discuss its phylogenetic placement. The 85 Mb genome is highly AT rich (GC content 25.71 %) and encodes a total of 11 397 protein- coding genes, of which 2793 could have their functions predicted with automated functional assignments. Functional annotation showed that M. cunhai can digest recalcitrant structural carbohydrates, nonstructural carbohydrates, and microbial cell walls, suggesting a role in diet metabolization and in microbial population control in the capybara's intestine. Moreover, the phylogenetic placement of M. cunhai provides insights on the origins of gigantism in the subclass Trichostomatia. (AU) | |
| FAPESP's process: | 20/11027-0 - Rumen microeukaryotic ciliates (Ciliophora, Entodiniomorphida, Ophryoscolecidae): phylogenomics and potential application in bioethanol industry |
| Grantee: | Vera Nisaka Solferini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 20/10682-5 - Ruminal microeukaryotes ciliates (Ciliophora, Entodiniomorphida, Ophryoscolecidae): phylogenomics and potential application in the bioethanol industry |
| Grantee: | Franciane Cedrola Vale |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 22/00538-0 - Ciliated protists: a new source of molecules with antimicrobial activities |
| Grantee: | Marcus Vinicius Xavier Senra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/17077-2 - Genomic signatures of adaptation in the Brazilian Dry Diagonal |
| Grantee: | Millke Jasmine Arminini Morales |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |