| Grant number: | 10/19547-1 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2011 |
| End date: | June 30, 2014 |
| Field of knowledge: | Biological Sciences - Parasitology - Protozoology of Parasites |
| Principal Investigator: | Munira Muhammad Abdel Baqui |
| Grantee: | Munira Muhammad Abdel Baqui |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract
Over the past decades, the trypanosomatids have been used as experimental models for cellular, biochemical and molecular studies. They also represent an excellent model for cell biology suitable for investigation analysis of basic questions about the cytoskeleton and its evolution in higher eukaryotes (Gull 1999, 2003). In the Trypanosomatidae family, we demonstrated the existence of a new class of high molecular mass phosphoproteins (1000-4000kDa), which besides having a structural role have been implicated in the regulation and organization of the cytoskeleton (Baqui e cols, 1996, 2000a, 2000b). These proteins are partially located in the flagellar pocket, in the flagellar adhesion region, suggesting involvement in cellular functions such as flagellar adhesion, endocytosis and exocytosis, capping of microtubules, cytokinesis among others. However, factors that interact with these proteins in both the cytoskeleton and the host are still unknown and little is known about the giant proteins of the pathogenic trypanosomatids and their functions. This project aims to investigate the biochemical, molecular and functional properties of the giant proteins of relevant pathogens such as Leishmania, Trypanosoma cruzi and T. brucei. (AU)
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