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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of temporal lobe structure volume on memory in elderly depressed patients

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Author(s):
Avila, Renata [1] ; Ribeiz, Salma [1] ; Duran, Fabio L. S. [2] ; Arrais, Jony P. J. [3] ; Moscoso, Marco A. A. [1] ; Bezerra, Diana M. [1] ; Jaluul, Omar [4] ; Castro, Claudio C. [5] ; Busatto, Geraldo F. [2] ; Bottino, Cassio M. C. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Projeto Terceira Idade PROTER, Old Age Res Grp, Inst & Dept Psychiat, BR-05403010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Psychiat Neuroimaging LIM21, Inst & Dept Psychiat, BR-05403010 Sao Paulo - Brazil
[3] Univ Fed Fluminense, Dept Stat, BR-24220000 Niteroi, RJ - Brazil
[4] Univ Sao Paulo, Dept Internal Med, Sch Med, BR-05403010 Sao Paulo - Brazil
[5] Univ Fed Fluminense, Dept Diagnost Imaging, Heart Inst InCor, BR-24220000 Niteroi, RJ - Brazil
Total Affiliations: 5
Document type: Journal article
Source: NEUROBIOLOGY OF AGING; v. 32, n. 10, p. 1857-1867, OCT 2011.
Web of Science Citations: 13
Abstract

Objective: To compare the volume of the hippocampus and parahippocampal gyrus in elderly individuals with and without depressive disorders, and to determine whether the volumes of these regions correlate with scores on memory tests. Method: Clinical and demographic differences, as well as differences in regional gray matter volumes, were assessed in 48 elderly patients with depressive disorders and 31 control subjects. Brain (structural MRI) scans were processed using statistical parametric mapping and voxel-based morphometry. Cognitive tests were administered to subjects in both groups. Results: There were no between-group gray matter volume differences in the hippocampus or parahippocampal gyrus. In the elderly depressed group only, the volume of the left parahippocampal gyrus correlated with scores on the delayed naming portion of the visual verbal learning test. There were also significant direct correlations in depressed subjects between the volumes of the left hippocampus, right and left parahippocampal gyrus and immediate recall scores on verbal episodic memory tests and visual learning tests. In the control group, there were direct correlations only between overall cognitive performance (as assessed with the MMSE) and the volume of right hippocampus, and between the total score on the visual verbal learning test and the volume of the right and left parahippocampal gyrus. Conclusions: These findings highlight different patterns of relationship between cognitive performance and volumes of medial temporal structures in depressed individuals and healthy elderly subjects. The direct correlation between delayed visual verbal memory recall scores with left parahippocampal volumes specifically in elderly depressed individuals provides support to the view that depression in elderly populations may be a risk factor for dementia. (C) 2009 Elsevier Inc. All rights reserved. (AU)