Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cobalt phthalocyanine as a biomimetic catalyst in the amperometric quantification of dipyrone using FIA

Full text
Boni, Ana Carolina [1] ; Wong, Ademar [1] ; Fireman Dutra, Rosa Amalia [2] ; Taboada Sotomayor, Maria Del Pilar [1]
Total Authors: 4
[1] State Univ Sao Paulo UNESP, Dept Analyt Chem, Inst Chem, BR-14801970 Araraquara, SP - Brazil
[2] Univ Pernambuco, Lab Diagnost Res IAPED, BR-50100130 Recife, PE - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Talanta; v. 85, n. 4, p. 2067-2073, SEP 30 2011.
Web of Science Citations: 22

A biomimetic sensor for the determination of dipyrone was prepared by modifying carbon paste with cobalt phthalocyanine (CoPc), and used as an amperometric detector in a flow injection analysis (FIA) system. The results of cyclic voltammetry experiments suggested that CoPc behaved as a biomimetic catalyst in the electrocatalytic oxidation of dipyrone, which involved the transfer of one electron. The optimized FIA procedure employed a flow rate of 1.5 mL min(-1), a 75 mu L sample loop, a 0.1 mol L(-1) phosphate buffer carrier solution at pH 7.0 and amperometric detection at a potential of 0.3 V vs. Ag/AgCl. Under these conditions, the proposed method showed a linear response for dipyrone concentrations in the range 5.0 x 10(-6)-6.3 x 10(-3) mol L(-1). Selectivity and interference studies were carried out in order to validate the system for use with pharmaceutical and environmental samples. In addition to being environmentally friendly, the proposed method is a sensitive and selective analytical tool for the determination of dipyrone. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 08/00303-5 - Construction of biomimetic sensors for drugs determination and their coupling in flow systems
Grantee:Maria Del Pilar Taboada Sotomayor
Support type: Regular Research Grants
FAPESP's process: 09/04598-2 - Development of a flow analytical methodology for dypirone determination in drugs and effluents using biomimetic sensor as highly selective detectors
Grantee:Ana Carolina Boni
Support type: Scholarships in Brazil - Scientific Initiation