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Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol

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Author(s):
Salvio, Ana Gabriela ; Stringasci, Mirian ; Requena, Michelle B. ; Fregolenti, Bianca A. ; Medeiro, Maira Monique da Costa ; Santos, Rosilene Guedes ; Bagnato, Vanderlei Salvador
Total Authors: 7
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 45, p. 3-pg., 2024-02-27.
Abstract

Significance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful. Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm2). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm2). Disease-free survival rate and pain score during irradiations were evaluated. Results: The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home. Conclusions: A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results. (AU)

FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 22/10860-6 - USE OF DISSOLVING MICRONEEDLES CONTAINING AMINOLEVULINIC ACID FOR PHOTODYNAMIC THERAPY
Grantee:Michelle Barreto Requena
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 23/04209-3 - Dissolving microneedles for nonmelanoma skin cancer and melanoma treatments with PDT and SDT: basic studies and pre-clinical experiments
Grantee:Michelle Barreto Requena
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor