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Textural features of basal cell carcinoma's chromatin

Grant number: 12/21929-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2013
Effective date (End): January 31, 2014
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Hélio Amante Miot
Grantee:Paola Jung Mendaçolli
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Basal cell carcinoma is the most common malignancy in men. It can present itself in many variants, such as superficial, infiltrating, sclerodermoid, micronodular and fibroepithelioma of pinkus: the first two ones have few aggressive characteristics and the other three ones have high morbidity. Basal cell carcinoma has low mortality, but high morbidity due to its local destructive potential and increased recurrence rate.Differences regarding the evolution among basal cell carcinoma's variants are not very well defined. Cell nuclei's morphological analysis by histology can provide relevant information on the physiology of the cell and, thus, help in the study of the diagnosis and prognosis of neoplastic lesions. Cellular modifications are seen together with changes in the nucleus' chromatin arrangement, and nuclear texture features have already been studied as prognostic factors in many malignancies.There are many mathematical tools to characterize and quantify an image's heterogeneity of texture, as the measure of entropy, histogram variation coefficient, textural estimators (Rq, Ra), components of co-occurrence matrix and fractal dimension.There are no researches in literature on the heterogeneity of nuclear chromatin of different basal cell carcinomas' subtypes.This study aims to evaluate heterogeneity of nuclear chromatin texture by many indexes, compare them between different subtypes of this malignancy and normal epithelium, among primary and recurrent basal cell carcinoma, and evaluate the correlation between the idexes of nuclear textures.Thirty nucleus of the adjacent epithelium and of each of the 165 malignancies will be photographed. The texture of nuclear chromatin of different basal cell carcinoma subtype and from the epithelium will be evaluated in order of fractal dimension calculus, percentage of variation coefficient, image entropy, the parameters of co-occurrence matrix and texture estimators (Ra, Rq).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDACOLLI, PAOLA JUNG; BRIANEZI, GABRIELLI; SCHMITT, JULIANO VILAVERDE; ALENCAR MARQUES, MARIANGELA ESTHER; MIOT, HELIO AMANTE. Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma. ANAIS BRASILEIROS DE DERMATOLOGIA, v. 90, n. 6, p. 874-878, NOV-DEC 2015. Web of Science Citations: 3.

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