Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system

Author(s)

Goncalves, Carlos E. da Silva ; Fock, Ricardo A.

• Document type: Journal article
• Source: CYTOKINE & GROWTH FACTOR REVIEWS; v. 76, p. 8-pg., 2024-03-25.

Abstract

The bone marrow is a haven for hematopoietic and non-hematopoietic cells, creating complex micro-anatomical regions called niches. These distinct niches all participate in an intricate orchestra of cellular interactions that regulates the hematopoietic stem cell and its progenies. In this review, we provide a detailed description of the three most well-known bone marrow niches and their participation in hematopoiesis. We use pre-clinical data, including different in vitro and in vivo studies to discuss how a group of proteins called Semaphorins could potentially modulate both hematopoietic and non-hematopoietic cells, establishing links between the niches, semaphorins, and hematopoietic regulation. Thus, here we provide a deep dive into the inner functioning of the bone marrow and discuss the overarching implications that semaphorins might have on blood formation. (AU)

• FAPESP's process: 23/03938-1 - Evaluation of the effects of protein malnutrition and renutrition over the control of hematopoiesis: participation of class 3 and 4 semaphorins
• Grantee: Carlos Eduardo da Silva Gonçalves
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/08658-1 - Influence of protein malnutrition in the elderly on the immunomodulatory aspects of mesenchymal stromal cells and their action in the regulation of hematopoiesis
• Grantee: Ricardo Ambrósio Fock
• Support Opportunities: Regular Research Grants